The formation of carbon-carbon bonds is of great importance for the development of pharmaceuticals and other biologically active molecules, and functional materials. In contrast to traditional cross-coupling chemistry, C–H activation requires no prefunctionalization of the substrates. However, the applicability of C–H activation chemistry has been limited mainly by the inert nature of the carbon-hydrogen bond. Our group has developed continuous-flow strategies to boost the reactivity of C–H activation chemistry.
Representative publications:
- C(sp3)–H Functionalizations of Light Hydrocarbons Using Decatungstate Photocatalysis in Flow Laudadio, G.; Deng, Y.; van der Wal, K.; Ravelli, D.; Nuño, M.; Fagnoni, M.; Guthrie, D.; Sun, Y. and Noël, T. Science. 2020, 369 (6499), 92-96
- De Novo Design of Organic Photocatalysts: Bithiophene Derivatives for the Visible‐light Induced C‐H Functionalization of Heteroarenes. Bottecchia, C.; Martin, R.; Abdiaj, I.; Crovini, E.; Alcazar, J.; Jorduna, J.; Blesa, M.; Carrillo, J.; Prieto, P. and Noël, T. Advanced Synthesis & Catalysis 2019, 361 (5), 945-950
- Selective C(sp3)-H Aerobic Oxidation enabled by Decatungstate Photocatalysis in Flow. Laudadio, G.; Govaerts, S.; Ying Wang, Y.; Ravelli, D.; Koolman, H.; Fagnoni, M.; Djuric, S. and Noël, T. Angewandte Chemie International Edition 2018, 57 (15), 4078-4082
- A Modular Flow Design for the meta-Selective C−H Arylation of Anilines. Gemoets, H. P. L.; Laudadio, G.; Verstraete, K.; Hessel, V. and Noël, T. Angewandte Chemie International Edition 2017, 56 (25), 7161-7165.
- Aerobic C–H Olefination of Indoles via a Cross-Dehydrogenative Coupling in Continuous Flow. Gemoets, H. P. L.; Hessel, V. and Noël, T. Organic Letters 2014, 16 (21), 5800-5803