2024
van der Heide, P.; Retini, M; Fanini, F; Piersanti, P; Secci, F; Mazzarella, D; Noël, T.; and Luridana A. Giese-type alkylation of dehydroalanine derivatives via silane-mediated alkyl bromide activation Beilstein Journal of Organic Chemistry, 2024, 20, 3274-3280, DOI: 10.3762/bjoc.20.271
Regnier, M.; Vega, C.; Ioannou, D.; Zhang, Z.; and Noël, T. Flow electroreductive nickel-catalyzed cyclopropanation of alkenes using gem-dichloroalkanes ChemRxiv, 2024, DOI: 10.26434/chemrxiv-2024-hvqtz
Schuurmans, J.; Zondag, S.; Chaudhuri, A.; Claros, M.; Van der Schaaf, J.; and Noël, T. Interaction of Light with Gas-Liquid Interfaces: Influence on Photon Absorption in Continuous-Flow Photoreactors ChemRxiv, 2024, DOI: 10.26434/chemrxiv-2024-k0x94
Regnier, M.; Vega, C.; Ioannou, D. I.; and Noël, T. Enhancing electrochemical reactions in organic synthesis: the impact of flow chemistry Chemical Society Reviews, 2024, 53, 10741-10760 DOI: 10.1039/D4CS00539B
Capaldo, L.; Wan, T.; Mulder, R.; Djossou, J. and Noël, T. Visible Light-Induced Halogen-Atom Transfer by N-Heterocyclic Carbene-Ligated Boryl Radicals for Diastereoselective C(sp3)–C(sp2) Bond Formation Chemical Science, 2024, 15, 14844-14850 DOI: 10.1039/D4SC02962C
Bayley,O.; Savino, E.; Slattery, A.; and Noël, T. Autonomous chemistry: Navigating self-driving labs in chemical and material sciences Matter, 2024, 7, 2382-2398, DOI: 10.1016/j.matt.2024.06.003
Masson,T.; Zondag, S.; Schuurmans, J.; and Noël, T. Open-source 3D printed reactors for reproducible batch and continuous-flow photon-induced chemistry: design and characterization Reaction Chemistry & Engineering, 2024, 9, 2218-2225 DOI: 10.1039/D4RE00081A
Pulcinella, A.; Tiwari, P.; Luridiana, A.; Yamazaki, K.; Mazzarella, D.; Sadhoe, A.; Alfano, A.; Tiekink, E.; Hamlin, T. and Noël, T. C1-4 Alkylation of Aryl Bromides with Light Alkanes enabled by Metallaphotocatalysis in Flow. Angewandte Chemie International Edition, 2024, e202413846, DOI: 10.1002/anie.202413846(For the preprint version, see 10.26434/chemrxiv-2024-7mk1c)
Spennacchio, M.; Bernus, M.; Stanic, J.; Mazzarella, D.; Colella, M.; Douglas, J.; Boutureira, O. and Noël, T. A Unified Flow Strategy for the Preparation and Use of Trifluoromethyl-heteroatom Anions. Science, 2024, 385, 991-996, DOI: 10.1126/science.adq2954(For the preprint version, see 10.26434/chemrxiv-2024-3bqt6)
Schuurmans, J.; Masson, T.; Zondag, S.; Pilon, S.; Bragato, N.; Claros, M.; den Hartog, T. Sastre, F.; van den Ham, J.; Buskens, P.; Fiorani. G. and Noël, T. Light-assisted carbon dioxide reduction in an automated photoreactor system coupled to carbonylation chemistry. Chemical Science, 2024, 15, 19842-19850 DOI: 10.1039/D4SC06660J (For the preprint version, see 10.26434/chemrxiv-2024-sz6ng)
Boronin, E. N.; Svetlakova, M. M.; Vorobyov, I. I.; Malysheva, Y. B.; Polushtaytsev, Y. V.; Mensov, S. N.; Vladimirovich Vorotyntsev, A.; Fedorov, A.; Noël, T. and Nyuchev, A. V. Photochemical organocatalytic heteroarylation of anilines and secondary alicyclic amines in continuous-flow. Reaction Chemistry & Engineering, 2024, 9, 1877-1882, DOI: 10.1039/D4RE00130C
Lukas, F.; Findlay, M.; Fillols, M.; Templ, J.; Savino, E.; Martin, B.; Allmendinger, S.; Furegati, M. and Noël, T. Graphitic carbon nitride as a photocatalyst for decarboxylative C(sp2)-C(sp3) couplings via nickel catalysis. Angewandte Chemie International Edition, 2024, e202405902, DOI: 10.1002/anie.202405902 (For the preprint version, see 10.26434/chemrxiv-2024-b7kv6)
Bonciolini, S.; Pulcinella, A.; Leone, M.; Schiroli, D.; Luguera Ruiz, A.; Sorato, A.; Dubois, M. A. J.; Gopalakrishnan, R.; Masson, G.; Della Ca’, N.; Protti, S.; Fagnoni, M.; Zysman-Colman, E.; Johansson, M. and Noël, T. Metal-free photocatalytic cross-electrophile coupling enables C1 homologation and alkylation of carboxylic acids with aldehydes. Nature Communications, 2024, 15 (1509), DOI: 10.1038/s41467-024-45804-z (For the preprint version, see 10.26434/chemrxiv-2023-fcl2j)
Nagornîi, D.; Raymenants, F.; Kaplaneris, N. and Noël, T. C(sp3)–H sulfinylation of light hydrocarbons with sulfur dioxide via hydrogen atom transfer photocatalysis in flow. Nature Communications, 2024, 15, 5246, DOI: 10.1038/s41467-024-49322-w (For the preprint version, see 10.26434/chemrxiv-2024-djx7b)
Kaplaneris, N.; Akdeniz, M.; Fillols, M.; Arrighi, F.; Raymenants, F.; Sanil, G.; Gryko, D. T. and Noël, T. Photocatalytic Functionalization of Dehydroalanine-Derived Peptides in Batch and Flow. Angewandte Chemie International Edition, 2024, e202403271, DOI: 10.1002/anie.202403271 (For the preprint version, see 10.26434/chemrxiv-2024-6fgqv)
Mazzarella, D.; Stanic, J.; Bernus, M.; Seyed Mehdi, A.; Henderson, C.; Boutureira, O. and Noël, T. In-flow generation of thionyl fluoride (SOF2) enables the rapid and efficient synthesis of acyl fluorides from carboxylic acids. JACS Au, 2024, 4, 8, 2989–2994, DOI: 10.1021/jacsau.4c00318(For the preprint version, see 10.26434/chemrxiv-2024-z41gc)
Alcázar, J.; Anderson, E. A.; Davies, H. M. L.; Febrian, R.; Kelly, C. B.; Noël, T.; Voight, E. A.; Zarate, C; and Zysman-Colman, E. Better Together: Catalyzing Innovation in Organic Synthesis via Academic-Industrial Consortia. Organic Letters, 2024, 26 (14), 2677–2681, DOI: 10.1021/acs.orglett.4c00192
Slattery, A; Wen, Z; Tenblad, P.; Pintossi, D.; Sanjose-Orduna, J.; den Hartog, T. and Noël, T. Automated self-optimization, intensification, and scale-up of photocatalysis in flow. Science, 2024, 383, DOI: 10.1126/science.adj1817 (For the preprint version, see 10.26434/chemrxiv-2023-r0drq)
Zondag, S.; Schuurman, J.; Chaudhuri, A.; Visser, R.; Soares, C.; Padoin, N.; Kuijpers, K.; Dorbec, M.; Van der Schaaf, J and Noël, T. Determining photon flux and effective optical path length in intensified flow photoreactors. Nature Chemical Engineering, 2024,1, 462–471 DOI: 10.1038/s44286-024-00089-3 (For the preprint version, see 10.26434/chemrxiv-2024-gfk84)
Anwar, K.; Capaldo, L.; Wan, T.; Noël, T. and Gómez-Suárez, Modular Synthesis of Congested β2,2-Amino Acids via the Merger of Photocatalysis and Oxidative Functionalisations. Chemical Communication, 2024, 60, 1456-1459, DOI: 10.1039/D3CC06172H (For the preprint version, see 10.26434/chemrxiv-2023-dbc9d)
Schuurmans, J.; Masson, T. M.; Zondag, S. D. A.; Buskens, P. and Noël, T. Solar-Driven Continuous CO2 Reduction to CO and CH4 using Heterogeneous Photothermal Catalysts: a Review Outlining Recent Progress and Remaining Challenges. ChemSusChem, 2024, 17 e202301405 DOI: 10.1002/cssc.202301405
Laporte, A.; Masson, T. M.; Zondag, S. D. A. and Noël, T. Multiphasic Continuous-Flow Reactors for Handling Gaseous Reagents in Organic Synthesis: Enhancing Efficiency and Safety in Chemical Processes. Angewandte Chemie International Edition, 2024, 63 e202316108 DOI: 10.1002/anie.202316108
Costa, R.; Vega, C.; Regnier, M.; Capaldo, L.; Wesenberg, L.; Lowe, G.; de Oliveira, K. and Noël, T. Electrosynthesis of Aryliminophosphoranes in Continuous Flow. Advanced Synthesis & Catalysis, 2024, 366, 955-960. DOI: 10.1002/adsc.202300635
Bernus, M.; Mazzarella, D.; Stanic, J.; Zhai, Z.; Vazquez A. Y.; Boutureira, O. Gargano, A. F. G.; Grossmann, T. and Noël, T. A modular flow platform for sulfur(VI) fluoride exchange ligation of small molecules, peptides and proteins. Nature Synthesis, 2024, 3, 185-191, DOI: 10.1038/s44160-023-00441-0 (For the preprint version, see 10.26434/chemrxiv-2023-gngqd)
Laktsevich-Iskryk, M.; Krech, A.; Fokin, M.; Kimm, M.; Jarg, T.; Noël, T. and Ošeka, M. Telescoped synthesis of vicinal diamines via ring-opening of electrochemically generated aziridines in flow. Journal of Flow Chemistry, 2024, 14, 139–147, DOI: 10.1007/s41981-023-00296-8
Wan, T.; Capaldo, L; Djossou, J.; Staffa, A.; de Zwart, F; de Bruin, B. and Noël, T. Rapid and Scalable Photocatalytic C(sp2)–C(sp3) Suzuki−Miyaura Cross-Coupling of Aryl Bromides with Alkyl Boranes. Nature Communications, 2024, 15, 4028 DOI: 10.1038/s41467-024-48212-5 (For the preprint version, see 10.26434/chemrxiv-2023-4g3xz)
Wesenberg, L. J.; Sivo, A.; Vilé, G. and Noël, T. Ni-Catalyzed Electro-Reductive Cross-Electrophile Couplings of Alkyl Amine-Derived Radical Precursors with Aryl Iodides. The Journal of Organic Chemistry, 2024, 89, 22, 16121-16125 DOI: 10.1021/acs.joc.3c00859
2023
Ioannou, D.; Capaldo, L.; Sanramat, J.; Reek, J. and Noël, T. Accelerated Electrophotocatalytic C(sp3)‒H Heteroarylation Enabled by an Efficient Continuous-Flow Reactor. Angewandte Chemie International Edition, 2023, 62, e202315881 DOI: 10.1002/anie.202315881 (For the preprint version, see 10.26434/chemrxiv-2023-1xbvv)
Capaldo, L.; Wen, Z. and Noël, T. A field guide to flow chemistry for synthetic organic chemists. Chemical Science, 2023, 14, 4230-4247 DOI: 10.1039/D3SC00992K
D. A. Zondag, S.; Mazzarella, D. and Noël, T. Scale-Up of Photochemical Reactions: Transitioning from Lab Scale to Industrial Production. Annual Review of Chemical and Biomolecular Engineering, 2023, 14, 283-300 DOI: 10.1146/annurev-chembioeng-101121-074313
Raymenants, F.; Masson, T.; San Jose Orduna, J. and Noël, T. Efficient C(sp3)-H carbonylation of light and heavy hydrocarbons with carbon monoxide via HAT photocatalysis in flow. Angewandte Chemie International Edition, 2023, e202308563 DOI: 10.1002/anie.202308563 (For the preprint version, see 10.26434/chemrxiv-2023-jbjh2)
West, T. Lights, flow, transfer. Nature Synthesis, 2023, 2, 198–199 DOI: 10.1038/s44160-022-00216-z (An interview with Timothy Noël about how flow technologies and photocatalytic methods enable C(sp3)–H functionalization reactions.)
Fanini, F.; Luridiana, A.; Mazzarella, D.; Alfano, A. I.; van der Heide, P.; Rincón, J. A.; García-Losada, P.; Mateos, C.; Frederick, M. O.; Nuño, M. and Noël, T. Flow photochemical Giese reaction via silane-mediated activation of alkyl bromides. Tetrahedron Letters 2023, 154380 DOI: 10.1016/j.tetlet.2023.154380
Pulcinella, A.; Bonciolini, S.; Lukas, F.; Sorato, A.; and Noël, T. Photocatalytic Alkylation of C(sp3)−H Bonds Using Sulfonylhydrazones. Angewandte Chemie International Edition 2023, 62 (3), e202215374 DOI: 10.1002/anie.202215374 (For the preprint version, see: 10.26434/chemrxiv-2022-h91bz)
Wan, T.; Capaldo, L.; Ravelli, D.; Vitullo, W.; de Zwart, F.; de Bruin, B. and Noël, T. Photoinduced Halogen-Atom Transfer (XAT) by N-heterocyclic carbene boryl radicals for C(sp3)−C(sp3) bond formation. Journal of the American Chemical Society 2023, 145 (2), 991–999 DOI: 10.1021/jacs.2c10444 (For the preprint version, see: 10.26434/chemrxiv-2022-8j1df)
2022
Sanjose-Orduna, J.; Silva, R. C.; Raymenants, F.; Reus, B.; Thaens, J.; de Oliveira, K. T.; and Noël, T. Dual role of benzophenone enables a fast and scalable C-4 selective alkylation of pyridines in flow Chemical Science 2022,13, 12527-12532 DOI: 10.1039/D2SC04990B
Luridiana, A.; Mazzarella, D.; Capaldo, L.; Rincón, J. A.; García-Losada, P.; Mateos, C.; Frederick, M. O.; Nuño, M.; Buma, W. J.and Noël, T. The Merger of Benzophenone HAT Photocatalysis and Silyl Radical-Induced XAT Enables Both Nickel-Catalyzed Cross-Electrophile Coupling and 1,2-Dicarbofunctionalization of Olefins. ACS Catalysis 2022, 12 (18), 11216–11225 DOI: 10.1021/acscatal.2c03805
Masson, T. M.; Zondag, S. D. A.; Debije, M. G. and Noël, T. Rapid and Replaceable Luminescent Coating for Silicon-Based Microreactors Enabling Energy-Efficient Solar Photochemistry. ACS Sustainable Chemistry & Engineering 2022 10 (32), 10712–10717 DOI: 10.1021/acssuschemeng.2c03390
Capaldo, L.; Bonciolini, S.; Pulcinella, A; Nuno, M. and Noël, T. Modular allylation of C(sp3)−H bonds by combining decatungstate photocatalysis and HWE olefination in flow. Chemical Science 2022, 13 (24), 7325-7331 DOI: 10.1039/D2SC01581A (For the preprint version, see: 10.26434/chemrxiv-2021-5vdm7)
Wen, Z.; Pintossi, D.; Nuno, M. and Noël, T. Membrane-based TBADT recovery: increasing the sustainability of continuous-flow photocatalytic HAT transformations. Nature Communications 2022, 13 (6147) DOI: 10.1038/s41467-022-33821-9 (For the preprint version, see: 10.26434/chemrxiv-2022-fdxzn)
Bonciolini, S.; Noël, T. and Capaldo, L. Synthetic Applications of Photocatalyzed Halogen-radical mediated Hydrogen Atom Transfer for C−H Bond Functionalization. European Journal of Organic Chemistry 2022, 2022 (34), e202200417 DOI: 10.1002/ejoc.202200417
Bajada, M. A.; Sanjosé-Orduna, J.; Di Liberto, G.; Tosoni, S.; Pacchioni, G.; Noël, T. and Vilé, G. Interfacing single-atom catalysis with continuous-flow organic electrosynthesis. Chemical Society Reviews 2022, 51 (10), 3898-3925 DOI: 10.1039/D2CS00100D
Riente, P.; Fianchini, M.; Pericàs, M. A. and Noël, T. Accelerating the Photocatalytic Atom Transfer Radical Addition Reaction Induced by Bi2O3 with Amines: Experiment and Computation. ChemCatChem 2022, 14 (12), e202200319 DOI: 10.1002/cctc.202200319
de Souza, A. A. N.; Bartolomeu, A. de A.; Brocksom, T. J.; Noël, T. and de Oliveira, K. T. Direct Synthesis of α-Sulfenylated Ketones under Electrochemical Conditions. The Journal of Organic Chemistry 2022, 87 (9), 5856-5865 DOI: 10.1021/acs.joc.2c00147
Capaldo, L.; Noël, T. and Ravelli, D. Photocatalytic generation of ligated boryl radicals from tertiary amine-borane complexes: An emerging tool in organic synthesis. Chem Catalysis 2022, 2 (5), 957-966 DOI: 10.1016/j.checat.2022.03.005
Kooli, A.; Wesenberg, L.; Beslać, M.; Krech, A.; Lopp, M.; Noël, T. and Ošeka, M. Electrochemical Hydroxylation of Electron-Rich Arenes in Continuous-Flow. European Journal of Organic Chemistry 2022, 2022 (20), e202200011 DOI: 10.1002/ejoc.202200011
Chaudhuri, A.; Zondag, S. D. A.; Schuurmans, J. H. A.; van der Schaaf, J.; and Noël, T. Scale-Up of a Heterogeneous Photocatalytic Degradation Using a Photochemical Rotor–Stator Spinning Disk Reactor. Organic Process Research & Development 2022, 26 (4), 1279-1288 DOI: 10.1021/acs.oprd.2c00012
Delparish, A.; Uslu, A.; Cao, Y.; de Groot, T.; van der Schaaf, J.; Noël, T. and Neira d’Angelo, M. F. Boosting the valorization of biomass and green electrons to chemical building blocks: A study on the kinetics and mass transfer during the electrochemical conversion of HMF to FDCA in a microreactor. Chemical Engineering Journal 2022, 135393 DOI: 10.1016/j.cej.2022.135393
Noël, T. and Zysman-Colman, E. The promise and pitfalls of photocatalysis for organic synthesis. Chem Catalysis 2022, 2 (3), 468-476 DOI: 10.1016/j.checat.2021.12.015
Wan, T.; Wen. Z.; Laudadio, G.; Capaldo, L.; Lammers, R.; Rincón, J. A.; García-Losada, P.; Mateos, C.; Frederick, M. O.; Boroersma, R. and Noël, T. Accelerated and Scalable C(sp3)–H Amination via Decatungstate Photocatalysis Using a Flow Photoreactor Equipped with High-Intensity LEDs. ACS Central Science 2022, 8 (1), 51-56 DOI: 10.1021/acscentsci.1c01109
Cao, Y.; Padoin, N.; Soares, C. and Noël, T. On the performance of liquid-liquid Taylor flow electrochemistry in a microreactor – A CFD study. Chemical Engineering Journal 2022, 427, 131443 DOI: 10.1016/j.cej.2021.131443
Zondag, S. D. A. ; Masson, T. M.; Debije, M. G. and Noël, T. The development of luminescent solar concentrator-based photomicroreactors: a cheap reactor enabling efficient solar-powered photochemistry. Photochem Photobiol Sci 2022, 21, 705–717 DOI: 10.1007/s43630-021-00130-x
Buglioni, L.; Raymenants, F.; Slattery, A.; Zondag, S. D. A. and Noël, T. Technological Innovations in Photochemistry for Organic Synthesis: Flow Chemistry, High-Throughput Experimentation, Scale-up, and Photoelectrochemistry. Chemical Reviews 2022, 122 (2), 2752-2906 DOI: 10.1021/acs.chemrev.1c00332
Dong, Z.; Zondag, S. D. A.; Schmid, M.; Wen, Z. and Noël, T. A Meso-Scale Ultrasonic Milli-Reactor Enables Gas-Liquid-Solid Photocatalytic Reactions in Flow. Chemical Engineering Journal 2022, 428, 130968 DOI: 10.1016/j.cej.2021.130968
2021
Laudadio, G.; Noël, T. Photochemical transformations in continuous-flow reactors. In Volume 2 Flow Chemistry – Applications; Darvas, F.; Dormán, G.; Hessel, V.; Ley, S.V. (Eds.), De Gruyter, 2021, 1-30. DOI: 10.1515/9783110693690-001
Masson, T. M.; Zondag, S. D. A.: Kuijpers, K. P. L.; Cambié, D.; G. Debije, M. and Noël, T. Development of an off-grid solar-powered autonomous chemical mini-plant for producing fine chemicals. ChemSusChem 2021, 14 (24), 5417-5423 DOI: 10.1002/cssc.202102011
Wen, Z.; Wan, T.; Vijeta, A.; Casadevall, C.; Buglioni, L.; Reisner, E. and Noël, T. Photocatalytic C–H Azolation of Arenes using Heterogeneous Carbon Nitride in Batch and Flow. ChemSusChem 2021, 14 (23), 5265-5270 DOI: 10.1002/cssc.202101767
Pulcinella, A.; Mazzarella, D. and Noël, T. Homogeneous Catalytic C(sp3)–H Functionalization of Gaseous Alkanes. Chemical Communications 2021, 57, 9956–9967 DOI: 10.1039/D1CC04073A.
Buglioni, L.; Beslać, M. and Noël, T. Dehydrogenative Azolation of Arenes in a Microflow Electrochemical Reactor. The Journal of Organic Chemistry 2021, 86 (22), 16195–16203 DOI: 10.1021/acs.joc.1c01409
Mazzarella, D.; Pulcinella, A.; Bovy, L.; Broersma, R. and Noël, T. Rapid and Direct Photocatalytic C(sp3)‒H Acylation and Arylation in Flow. Angewandte Chemie International Edition 2021, 60 (39), 21277-21282 DOI: 10.1002/anie.202108987
Wan, T.; Capaldo, L.; Laudadio, G.; Nyuchev, A.; Rincon, J.; Garcia-Losada, P.; Mateos Gutierrez, C.; O. Frederick, M.; Nuno, M. and Noël, T. Decatungstate-Mediated C(sp3)‒H Heteroarylation via Radical-Polar Crossover in Batch and Flow. Angewandte Chemie International Edition 2021, 60 (33), 17893–17897 DOI: 10.1002/anie.202104682
Dong, Z.; Wen, Z.; Zhao, F.; Kuhn, S. and Noël, T. Scale-up of Micro- and Milli-Reactors: An Overview of Strategies, Design Principles and Applications. Chemical Engineering Science: X 2021, 100097 DOI: 10.1016/j.cesx.2021.100097
Sambiagio, C.; Ferrari, M.; van Beurden, K.; Ca’, N. della; van Schijndel, J. and Noël, T. Continuous-Flow Synthesis of Pyrylium Tetrafluoroborates: Application to Synthesis of Katritzky Salts and Photoinduced Cationic RAFT Polymerization. Organic Letters 2021, 23 (6), 2042–2047 DOI: 10.1021/acs.orglett.1c00178
Riente, P.; Fianchini, M.; Llanes, P.; Pericàs, M. A. and Noël, T. Shedding Light on the Nature of the Catalytically Active Species in Photocatalytic Reactions Using Bi2O3 Semiconductor. Nature Communications 2021, 12, 625 DOI: 10.1038/s41467-020-20882-x
Oseka, M.; Laudadio, G.; van Leest, N. P.; Dyga, M.; de Andrade Bartolomeu, A.; Goossen, L.; de Bruin, B.; Thiago de Oliveira, K. and Noël, T. Electrochemical Aziridination of Internal Alkenes with Primary Amines. Chem 2021, 7 (1), 255–266 DOI: 10.1016/j.chempr.2020.12.002 (For the preprint version, see: 10.26434/chemrxiv.12824135.v1)
Cao, Y.; Knijff, J.; Delparish, A.; Neira d’Angelo, M. F. and Noël, T. A Divergent Paired Electrochemical Process for the Conversion of Furfural Using a Divided-Cell Flow Microreactor. ChemSusChem 2021, 14 (2), 590–594 DOI: 10.1002/cssc.202002833
Kuijpers, K. P. L.; Weggemans, W. M. A.; Verwijlen, C. J. A. and Noël, T. Flow Chemistry Experiments in the Undergraduate Teaching Laboratory: Synthesis of Diazo Dyes and Disulfides. Journal of Flow Chemistry 2021, 11, 7-12 DOI: 10.1007/s41981-020-00118-1
Shahbazali, E.; Billaud, E. M. F.; Fard, A. S.; Meuldijk, J.; Bormans, G.; Noël, T. and Hessel, V. Photo Isomerization of Cis-Cyclooctene to Trans-Cyclooctene: Integration of a Micro-Flow Reactor and Separation by Specific Adsorption. AIChE Journal 2021, 67 (1), e17067 DOI: 10.1002/aic.17067
Cao, Y.; Soares, C.; Padoin, N. and Noël, T. Gas Bubbles Have Controversial Effects on Taylor Flow Electrochemistry. Chemical Engineering Journal 2021, 406, 126811 DOI: 10.1016/j.cej.2020.126811
2020
Baker, M. J.; Gempf, K. L.; McDonald, H.; Kerr, H. E.; Hodges, C.; Anastasaki, A.; Noël, T. and Randviir, E. P. Five Years of the #RSCPoster Twitter Conference. Chemical Communications 2020, 56 (89), 13681–13688 DOI: 10.1039/D0CC90441D
Wen, Z.; Maheshwari, A.; Sambiagio, C.; Deng, Y.; Laudadio, G.; van Aken, K.; Sun, Y.; Gemoets, H. P. L. and Noël, T. Optimization of a Decatungstate-Catalyzed C(sp3)-H Alkylation Using a Continuous Oscillatory Milli-Structured Photoreactor. Organic Process Research & Development 2020, 24 (10), 2356–2361 DOI: 10.1021/acs.oprd.0c00235
Laudadio, G.; Deng, Y.; van der Wal, K.; Ravelli, D.; Nuño, M.; Fagnoni, M.; Guthrie, D.; Sun, Y. and Noël, T. C(sp3)–H Functionalizations of Light Hydrocarbons Using Decatungstate Photocatalysis in Flow. Science 2020, 369 (6499), 92-96 DOI: 10.1126/science.abb4688
van Schijndel, J.; Molendijk, D.; van Beurden, K.; Vermeulen, R.; Noël, T. and Meuldijk, J. Repeatable Molecularly Recyclable Semi-Aromatic Polyesters Derived from Lignin. Journal of Polymer Science 2020, 58 (12), 1655–1663 DOI: 10.1002/pol.20200088
Nyuchev, A. V; Wan, T.; Cendón, B.; Sambiagio, C.; Struijs, J. J. C.; Ho, M.; Gulías, M.; Wang, Y. and Noël, T. Photocatalytic Trifluoromethoxylation of Arenes and Heteroarenes in Continuous-Flow. Beilstein Journal of Organic Chemistry. 2020, 16, 1305–1312 DOI: 10.3762/bjoc.16.111
Rivas, D.F.; Noël, T et al. Process Intensification Education Contributes to Sustainable Development Goals. Part 2. Education for Chemical Engineers 2020, 32, 15–24 DOI: 10.1016/j.ece.2020.05.001
Rivas, D.F.; Noël, T et al. Process Intensification Education Contributes to Sustainable Development Goals. Part 1. Education for Chemical Engineers 2020, 32, 1–14 DOI: 10.1016/j.ece.2020.04.003
Sap, J. B. I.; Straathof, N. J. W.; Knauber, T.; Meyer, C. F.; Medebielle, M.; Buglioni, L.; Genicot, C.; Trabanco, A. A.; Noël, T.; am Ende, C. W. and Gouverneur, V. Organophotoredox Hydrodefluorination of Trifluoromethylarenes with Translational Applicability to Drug Discovery. Journal of the American Chemical Society 2020, 142(20), 9181-9187 DOI: 10.1021/jacs.0c03881
Schönbauer, D.; Sambiagio, C. Noël, T. and Schnürch, M. Photocatalytic Deaminative Benzylation and Alkylation of Tetrahydroisoquinolines with N-alkylpyrydinium Salts. Beilstein Journal of Organic Chemistry 2020, 16, 809–817 DOI: 10.3762/bjoc.16.74
Cao, Y.; Adriaenssens, B.; de A. Bartolomeu, A.; Laudadio, G.; de Oliveira, K. T. and Noël, T. Accelerating Sulfonyl Fluoride Synthesis through Electrochemical Oxidative Coupling of Thiols and Potassium Fluoride in Flow. Journal of Flow Chemistry 2020, 10, 191-197 DOI: 10.1007/s41981-019-00070-9
Govaerts, S.; Nyuchev, A. and Noël, T. Pushing the Boundaries of C–H Bond Functionalization Chemistry Using Flow Technology. Journal of Flow Chemistry 2020, 10, 13-71 DOI: 10.1007/s41981-020-00077-7
van Schijndel, J.; Molendijk, D.; van Beurden, K.; Alberto Canalle, L.; Noël, T. and Meuldijk, J. Preparation of Bio-Based Styrene Alternatives and Their Free Radical Polymerization. European Polymer Journal 2020, 125, 109534 DOI: 10.1016/j.eurpolymj.2020.109534
Sambiagio, C. and Noël, T. Flow Photochemistry: Shine Some Light on Those Tubes! Trends in Chemistry 2020, 2(2), 92-106 DOI: 10.1016/j.trechm.2019.09.003
Chaudhuri, A.; Kuijpers, K. P. L.; Hendrix, R.; Hacking, J.; Shivaprasad, P.; Emanuelsson, E. A. C.; Noël, T. and Schaaf, J. van der. Process Intensification of Photochemical Oxidations Using a High Throughput Rotor-Stator Spinning Disk Reactor: A Strategy for Scale Up. Chemical Engineering Journal 2020, 400, 125875 DOI: 10.1016/j.cej.2020.125875 (For the preprint version, see: 10.26434/chemrxiv.11560224.v1)
Hell, S. M.; Meyer, C. F.; Laudadio, G.; Misale, A.; Willis, M. C.; Noël, T.; Trabanco, A. A. and Gouverneur, V. Silyl Radical-Mediated Activation of Sulfamoyl Chlorides Enables Direct Access to Aliphatic Sulfonamides from Alkenes. Journal of the American Chemical Society 2020, 142(2), 720-725 DOI: 10.1021/jacs.9b13071
Zhang, C.; Song, Z.; Jin, C.; Nijhuis, J.; Zhou, T.; Noël, T.; Gröger, H.; Sundmacher, K.; van Hest, J. and Hessel, V. Screening of Functional Solvent System for Automatic Aldehyde and Ketone Separation in Aldol Reaction: A Combined COSMO-RS and Experimental Approach. Chemical Engineering Journal 2020, 385, 123399 DOI: 10.1016/j.cej.2019.123399
de Oliveira, G. X.; Lira, J. O. B.; Cambié, D.; Noël, T.; Riella, H. G.; Padoin, N. and Soares, C. CFD Analysis of a Luminescent Solar Concentrator-Based Photomicroreactor (LSC-PM) with Feedforward Control Applied to the Synthesis of Chemicals under Fluctuating Light Intensity. Chemical Engineering Research and Design 2020, 153, 626-634 DOI: 10.1016/j.cherd.2019.10.047
2019
Noël, T.; Cao, Y.; Laudadio, G. The Fundamentals Behind the Use of Flow Reactors in Electrochemistry. Accounts of Chemical Research 2019, 52 (10), 2858-2869 DOI: 10.1021/acs.accounts.9b00412
Deng, Y.; Wei, X.-J.; Wang, X.; Sun, Y.; Noël, T. Iron-Catalyzed Cross-Coupling of Alkynyl and Styrenyl Chlorides with Alkyl Grignard Reagents in Batch and Flow. Chemistry – A European Journal 2019, 25 (64), 14532-14535 DOI: 10.1002/chem.201904480
Riente Paiva, P. and Noël, T. Application of Metal Oxide Semiconductors in Light-Driven Organic Transformations. Catalysis Science & Technology 2019, 9, 5186-5232 DOI: 10.1039/c9cy01170f
Cambie, D.; Dobbelaar, J.; Riente Paiva, P.; Vanderspikken, J.; Shen, C.; Seeberger, P.; Gilmore, K.; Debije, M. and Noël, T. Energy-Efficient Solar Photochemistry with Luminescent Solar Concentrator-Based Photomicroreactors. Angewandte Chemie International Edition 2019, 58 (40), 14374-14378 DOI: 10.1002/anie.201908553
Bartolomeu, A. de A.; Silva, R. C.; Brocksom, T. J.; Noël, T. and de Oliveira, K. T. Photoarylation of Pyridines Using Aryldiazonium Salts and Visible Light: An EDA Approach. Journal of Organic Chemistry 2019, 84 (16), 10459-10471 DOI: 10.1021/acs.joc.9b01879
Laudadio, G.; Bartolomeu, A. de A.; Verwijlen, L. M. H. M.; Cao, Y.; de Oliveira, K. T. and Noël, T. Sulfonyl Fluoride Synthesis through Electrochemical Oxidative Coupling of Thiols and Potassium Fluoride. Journal of the American Chemical Society 2019, 141 (30), 11832-11836 DOI: 10.1021/jacs.9b06126
Wei, X.-J.; Abdiaj, I.; Sambiagio, C.; Li, C.; Zysman-Colman, E.; Alcazar, J. and Noël, T. Visible Light-promoted Fe-catalyzed Csp2-Csp3 Kumada Cross-Coupling in Flow. Angewandte Chemie International Edition 2019, 58 (37), 13030-13034 DOI: 10.1002/anie.201906462
Laudadio, G.; Barmpoutsis, E.; Schotten, C.; Struik, L.; Govaerts, S.; Browne, D.L. and Noël, T. Sulfonamide Synthesis through Electrochemical Oxidative Coupling of Amines and Thiols. Journal of the American Chemical Society 2019, 141 (14), 5664–5668 DOI: 10.1021/jacs.9b02266
Cao, Y. and Noël, T. Efficient Electrocatalytic Reduction of Furfural to Furfuryl Alcohol in a Microchannel Flow Reactor. Organic Process Research & Development 2019, 23 (3), 403-408 DOI: 10.1021/acs.oprd.8b00428
Bottecchia, C.; Martin, R.; Abdiaj, I.; Crovini, E.; Alcazar, J.; Jorduna, J.; Blesa, M.; Carrillo, J.; Prieto, P. and Noël, T. De Novo Design of Organic Photocatalysts: Bithiophene Derivatives for the Visible‐light Induced C‐H Functionalization of Heteroarenes. Advanced Synthesis & Catalysis 2019, 361 (5), 945-950 DOI: 10.1002/adsc.201801571
Bottecchia, C. and Noël, T. Photocatalytic Modification of Amino Acids, Peptides and Proteins. Chemistry – A European Journal 2019, 25 (1), 26-42 DOI: 10.1002/chem.201803074.
2018
Cambié, D. and Noël, T. Solar Photochemistry in Flow. Topics in Current Chemistry 2018, 376:45 DOI: 10.1007/s41061-018-0223-2.
Laudadio, G.; De Smet, W.; Struik, L.; Cao, Y. and Noël, T. Design and Application of a Modular and Scalable Electrochemical Flow Microreactor. Journal of Flow Chemistry 2018, 8(3), 157-165 DOI: 10.1007/s41981-018-0024-3.
Bottecchia, C. and Noël, T. Intermolecular Transition-Metal-Catalyzed C–C Coupling Reactions in Continuous Flow. Science of Synthesis: Flow Chemistry in Organic Synthesis 2018, 313, 313-346 DOI: 10.1055/sos-SD-228-00200.
Booker‐Milburn, K. and Noël, T. Flow Photochemistry. ChemPhotoChem 2018, 2 (10), 830-830 DOI: 10.1002/cptc.201800184.
Casnati, A.; Gemoets, H.P.L.; Motti, E.; Della Ca, N. and Noël, T. Homogeneous and Gas‐Liquid Catellani‐type Reaction Enabled by Continuous‐Flow Chemistry. Chemistry – A European Journal 2018, 24(53), 14079-14083 DOI: 10.1002/chem.201803909.
Wei, X.-J. and Noël, T. Visible-Light Photocatalytic Difluoroalkylation-induced 1, 2-Heteroarene Migration of Allylic Alcohols in Batch and Flow. Journal of Organic Chemistry 2018, 83, 11377-11384 DOI: 10.1021/acs.joc.8b01624.
Kuijpers K.P.L.; Bottecchia, C.; Cambié, D.; Drummen, K.; Koenig, N. and Noël, T. A fully automated continuous‐flow platform for fluorescence quenching studies and Stern‐Volmer analysis. Angewandte Chemie International Edition 2018, 57(35), 11278-11282 DOI: 10.1002/anie.201805632.
Escribà Gelonch, M.; Halpin, A.; Noël, T.; Hessel, V. Laser mediated photo‐high‐p,T intensification of Vitamin D₃ synthesis in continuous‐flow. ChemPhotoChem 2018, 2 (10), 922-930 DOI: 10.1002/cptc.201800102.
Straathof, N.J.W. and Noël, T. In “Visible light photocatalysis in organic chemistry”, Stephenson, C.R.J.; Yoon, T.; MacMillan, D.W.C. Wiley-VCH, Berlin, 2018, pp. 389-413 DOI: 10.1002/9783527674145.ch13.
Zhao, F.; Cambié, D.; Hessel, V.; Debije M.G.; Noël, T. Real-time reaction control for solar production of chemicals under fluctuating irradiance. Green Chemistry 2018, 20, 2459-2464 DOI: 10.1039/C8GC00613J.
van Schie, M.M.C.H.; Pedroso de Almeida, P.; Laudadio, G.; Tieves, F.; Fernández-Fueyo, E.; Noël, T.; Arends, I.W.C.E.; Hollmann, F. Biocatalytic synthesis of the Green Note trans-2-hexenal in a continuous-flow microreactor. Beilstein Journal of Organic Chemistry 2018, 14, 697-703 DOI: 10.3762/bjoc.14.58.
Laudadio, G.; Govaerts, S.; Ying Wang, Y.; Ravelli, D.; Koolman, H.; Fagnoni, M.; Djuric, S.; Noël, T. Selective sp3 C-H Aerobic Oxidation enabled by Decatungstate Photocatalysis in Flow. Angewandte Chemie International Edition 2018, 57 (15), 4078-4082 DOI: 10.1002/anie.201800818.
Escribà-Gelonch, M.; Hessel, V.; Maier, M.C.; Noël, T.; Neira D’Angelo, M.F.; Gruber-Woelfler, H. Continuous-flow in-line solvent-swap crystallization of Vitamin D3. Organic Process Research & Development 2018, 22 (2), 178-189 DOI: 10.1021/acs.oprd.7b00351.
Escribà-Gelonch, M.; Noël, T.; Hessel, V. Micro-flow high-p,T intensification of Vitamin D3 synthesis using a ultraviolet lamp. Organic Process Research & Development 2018, 22 (2), 147-155 DOI: 10.1021/acs.oprd.7b00318.
Zhao, F.; Cambié, D.; Janse, J.; Wieland, E.; Kuijpers, K.P.L.; Hessel, V.; Debije, M.G. and Noël, T. Scale up of a luminescent solar concentrator based photomicroreactor via numbering-up. ACS Sustainable Chemistry & Engineering 2018, 6 (1), 422–429, DOI: 10.1021/acssuschemeng.7b02687.
2017
Noël, T. A personal perspective on the future of flow photochemistry. Journal of Flow Chemistry 2017, 7 (3–4), 87–93, DOI: 10.1556/1846.2017.00022.
Wei, X-J.; Boon, W; Hessel, V.; Noël, T. Visible-Light Photocatalytic Decarboxylation of α,β-Unsaturated Carboxylic Acids: Facile access to Stereoselective Difluoromethylated Styrenes in Batch and Flow. ACS Catalysis 2017, 7, 7136–7140, DOI: 10.1021/acscatal.7b03019.
Laudadio, G.; Noël, T. Chapter 7 – Flow Chemistry Perspective for C-H Bond Functionalization. Strategies for Palladium-Catalyzed Non-Directed and Directed C-H Bond Functionalization 2017, 275-288, DOI: 10.1016/B978-0-12-805254-9.00007-4.
Bottecchia, C.; Rubens, M.; Gunnoo, S.; Hessel, V.; Madder, A.; Noël, T. Visible Light-Mediated Selective Arylation of Cysteine in Batch and Flow. Angewandte Chemie International Edition 2017, 56 (41), 12701-12707, DOI: 10.1002/anie.201706700.
Abdiaj, I.; Bottecchia, C.; Alcazar, J.; Noël, T. Visible-Light-Induced Trifluoromethylation of Highly Functionalized Arenes and Heteroarenes in Continuous Flow. Synthesis 2017, 49, 4978-4985, DOI: 10.1055/s-0036-1588527.
Laudadio, G.; Straathof, N.J.W.; Lanting, M.D.; Knoops, B.; Hessel, V.; Noël, T. An environmentally benign and selective electrochemical oxidation of sulfides and thiols in a continuous-flow microreactor. Green Chemistry 2017, 19, 4061 – 4066, DOI: 10.1039/C7GC01973D.
Laudadio, G.; Gemoets, H.P.L.; Hessel, V.; Noël, T. A Flow Synthesis of Diaryliodonium Triflates. Journal of Organic Chemistry 2017, 82, 11735-11741, DOI: 10.1021/acs.joc.7b01346.
Cambié, D.; Zhao, F.; Hessel, V.; Debije, M.G.; Noël, T. Every photon counts: understanding and optimizing photon paths in luminescent solar concentrator-based photomicroreactors (LSC-PMs). Reaction Chemistry & Engineering 2017, 2, 561-566, DOI: 10.1039/C7RE00077D.
Gruber-Wölfler, H.; Escriba-Gelonch, M.; Noël, T.; Maier, M.C.; Hessel, V. Effect of acetonitrile-based crystallization conditions on the crystal quality of Vitamin D3. Chemical Engineering & Technology 2017, 40(11), 2016-2024 DOI: 10.1002/ceat.201700080.
Gemoets, H. P. L.; Laudadio, G.; Verstraete, K.; Hessel, V.; Noël, T. A Modular Flow Design for the meta-Selective C−H Arylation of Anilines. Angewandte Chemie International Edition 2017, 56 (25), 7161-7165 DOI: 10.1002/anie.201703369.
Adouama, C.; Keyrouz, R.; Pilet, G.; Monnereau, C.; Gueyrard, D.; Noël, T. and Médebielle M. Access to cyclic gem-difluoroacyl scaffolds via electrochemical and visible light photocatalytic radical tandem cyclization of heteroaryl chlorodifluoromethyl ketones. Chemical Communications 2017, 53, 5653-5656 DOI: 10.1039/C7CC02979A.
Sharma, U. K.; Gemoets, H.P.L.; Schröder, F.; Noël, T. and Van der Eycken, E.V. Merger of Visible Light Photoredox Catalysis and C–H Activation for the Room Temperature C-2 Acylation of Indoles in Batch and Flow. ACS Catalysis 2017, 7, 3818-3823 DOI: 10.1021/acscatal.7b00840.
Kockmann, N.; Thenée, P.; Fleischer-Trebes, C.; Laudadio, G. and Noël, T. Safety Assessment in Development and Operation of Modular Continuous-Flow Processes. Reaction Chemistry & Engineering 2017, 2, 258-280 DOI: 10.1039/C7RE00021A.
Kuijpers, K.P.L.; van Dijk, M.A.H.; Rumeur, Q.; Hessel, V.; Su, Y. and Noël, T. A sensitivity analysis of a numbered-up photomicroreactor system. Reaction Chemistry & Engineering 2017, 2, 109-115 DOI: 10.1039/C7RE00024C.
Cambié, D.; Zhao, F.; Hessel, V.; Debije, M. G.; Noël, T. A leaf-inspired luminescent solar concentrator for energy-efficient continuous-flow photochemistry. Angewandte Chemie International Edition 2017, 56 (4), 1050-1054 DOI: 10.1002/anie.201611101.
Billaud, E.; Shahbazali, E.; Ahamed, M.; Cleeren, F.; Noël, T.; Koole, T.; Verbruggen, A.; Hessel, V.; Bormans, G. Micro-Flow Photosynthesis of New Dienophiles for Inverse-Electron-Demand Diels-Alder Reactions. Potential applications for pretargeted in vivo PET imaging. Chemical Science 2017, 8, 1251-1258 DOI: 10.1039/C6SC02933G.
Gemoets, H. P. L.; Kalvet, I.; Nyuchev, A.; Erdmann, N.; Hessel, V.; Schoenebeck, F.; Noël, T. Mild and selective base-free C–H arylation of heteroarenes: Experiment and computation. Chemical Science 2017, 8, 1046-1055 DOI: 10.1039/C6SC02595A.
Deng, Y.; Wei, X-J.; Wang, H.; Sun, Y.; Noël, T.; Wang, X. Disulfide-Catalyzed Visible-Light-Mediated Oxidative Cleavage of C=C Bonds and Evidence of an Olefin–Disulfide Charge-Transfer Complex. Angewandte Chemie International Edition 2017, 56 (3), 832-836 DOI: 10.1002/anie.201607948.
Shang, M.; Noël, T.; Su, Y.; Hessel, V. Kinetic study of hydrogen peroxide decomposition at high temperatures and concentrations in two capillary microreactors. AIChE Journal 2017, 63 (2), 689-697 DOI: 10.1002/aic.15385.
2016
Straathof, N. J. W.; Cramer, S. E.; Hessel, V.; Noël, T. Practical Photocatalytic Trifluoromethylation and Hydrotrifluoromethylation of Styrenes in Batch and Flow. Angewandte Chemie International Edition 2016, 55 (50), 15549-15553 DOI: 10.1002/anie.201608297.
Gemoets, H.P.L.; Hessel, V.; Noël, T. Reactor Concepts for Aerobic Liquid Phase Oxidation: Microreactors and Tube Reactors In Liquid Phase Aerobic Oxidation Catalysis – Industrial applications and academic perspectives, Stahl, S. S.; Alsters, P. L., Eds, Wiley-VCH, Berlin, 2016, 399-419, DOI: 10.1002/9783527690121.ch23.
Shahbazali, E.; Noël, T.; Hessel, V. Photo-Claisen rearrangement of allyl phenyl ether in microflow: Influence of phenyl core substituents and vision on orthogonality. Journal of Flow Chemistry 2016, 6 (3), 252-259 DOI: 10.1556/1846.2016.00029.
Su, Y.; Kuijpers, K.P.L.; Koenig, N.; Shang, M.; Hessel, V.; Noël, T. A mechanistic investigation of the visible light photocatalytic trifluoromethylation of heterocycles using CF3I in flow. Chemistry – A European Journal 2016, 22 (35), 12295-12300 DOI: 10.1002/chem.201602596.
Bottecchia, C.; Erdmann, N.; Tijssen, P. M. A.; Milroy, L-G.; Brunsveld, L.; Hessel, V.; Noël, T. Batch and flow synthesis of disulfides by visible light induced TiO2 photocatalysis. ChemSusChem 2016, 9 (14), 1781-1785 DOI: 10.1002/cssc.201600602.
Bottecchia, C.; Wei, X-J.; Kuijpers, K. P. L.; Hessel, V.; Noël, T. Visible light-induced trifluoromethylation and perfluoroalkylation of cysteine residues in batch and continuous flow. Journal of Organic Chemistry 2016, 81 (16), 7301-7307 DOI: 10.1021/acs.joc.6b01031.
Borukhova, S.; Noël, T.; Metten, B.; De Vos, E.; Hessel, V. From alcohol to 1,2,3-triazole via multi-step continuous-flow synthesis of rufinamide precursor. Green Chemistry 2016, 18, 4947-4953 DOI: 10.1039/C6GC01133K.
Su, Y.; Kuijpers, K. P. L.; Hessel, V.; Noël, T. A convenient numbering-up strategy for the scale-up of gas–liquid photoredox catalysis in flow. Reaction Chemistry & Engineering 2016, 1, 73-81 DOI: 10.1039/C5RE00021A.
Borukhova, S.; Noël, T.; Hessel, V. Hydrogen Chloride Gas in Solvent-Free Continuous Conversion of Alcohols to Chlorides in Microflow. Organic Process Research & Development 2016, 20 (2), 568-573 DOI: 10.1021/acs.oprd.6b00014.
Noël, T.; Su, Y.; Hessel, V. Beyond Organometallic Flow Chemistry: The Principles Behind the Use of Continuous-Flow Reactors for Synthesis. Topics in Organometallic Chemistry 2016, 57, 1-41 DOI: 10.1007/3418_2015_152.
Cambié, D.; Bottecchia, C.; Straathof, N. J. W.; Hessel, V.; Noël, T. Applications of Continuous-Flow Photochemistry in Organic Synthesis, Material Science, and Water Treatment. Chemical Reviews 2016, 116 (17), 10276-10341 DOI: 10.1021/acs.chemrev.5b00707.
Straathof, N. J. W.; Su, Y.; Hessel, V.; Noël, T. Accelerated gas-liquid visible light photoredox catalysis with continuous-flow photochemical microreactors. Nature Protocols 2016, 11 (1), 10-21 DOI: 10.1038/nprot.2015.113.
Gemoets, H. P. L.; Su, Y.; Shang, M.; Hessel, V.; Luque, R.; Noël, T. Liquid phase oxidation chemistry in continuous-flow microreactors. Chemical Society Reviews 2016, 45 (1), 83-117 DOI: 10.1039/C5CS00447K.
Vural Gürsel, I.; Kurt, S. K.; Aalders, J.; Wang, Q.; Noël, T.; Nigam, K. D. P.; Kockmann, N.; Hessel, V. Utilization of milli-scale coiled flow inverter in combination with phase separator for continuous flow liquid–liquid extraction processes. Chemical Engineering Journal 2016, 283, 855-868 DOI: 10.1016/j.cej.2015.08.028.
Borukhova, S.; Noël, T.; Hessel, V. Continuous-Flow Multistep Synthesis of Cinnarizine, Cyclizine, and a Buclizine Derivative from Bulk Alcohols. ChemSusChem 2016, 9 (1), 67-74 DOI: 10.1002/cssc.201501367.
Stouten, S. C.; Noël, T.; Wang, Q.; Beller, M.; Hessel, V. Continuous ruthenium-catalyzed methoxycarbonylation with supercritical carbon dioxide. Catalysis Science & Technology 2016, 6, 4712-4717 DOI: 10.1039/C5CY01883H.
Shang, M.; Noël, T.; Su, Y.; Hessel, V. High Pressure Direct Synthesis of Adipic Acid from Cyclohexene and Hydrogen Peroxide via Capillary Microreactors. Industrial & Engineering Chemistry Research 2016, 55 (10), 2669-2676 DOI: 10.1021/acs.iecr.5b04813.
Erdmann, N.; Su, Y.; Bosmans, B.; Hessel, V.; Noël, T. Palladium-catalyzed aerobic oxidative coupling of o-xylene in flow: a safe and scalable protocol for cross-dehydrogenative coupling. Organic Process Research & Development 2016, 20 (4), 831-835 DOI: 10.1021/acs.oprd.6b00044.
2015
Shang, M.; Noël, T.; Wang, Q.; Su, Y.; Miyabayashi, K.; Hessel, V.; Hasebe, S. 2- and 3-Stage temperature ramping for the direct synthesis of adipic acid in micro-flow packed-bed reactors. Chemical Engineering Journal 2015, 260, 454-462 DOI: 10.1016/j.cej.2014.08.061.
Shahbazali, E.; Spapens, M.; Kobayashi, H.; Ookawara, S.; Noël, T.; Hessel, V. Connected nucleophilic substitution-Claisen rearrangement in flow – Analysis for kilo-lab process solutions with orthogonality. Chemical Engineering Journal 2015, 281, 144-154 DOI: 10.1016/j.cej.2015.06.020.
Stouten, S. C.; Noël, T.; Wang, Q.; Hessel, V. Supported Liquid Phase Catalyst coating in micro flow Mizoroki–Heck reaction. Chemical Engineering Journal 2015, 279, 143-148 DOI: 10.1016/j.cej.2015.05.026.
Su, Y.; Hessel, V.; Noël, T. A compact photomicroreactor design for kinetic studies of gas-liquid photocatalytic transformations. AIChE Journal 2015, 61 (7), 2215-2227 DOI: 10.1002/aic.14813.
Talla, A.; Driessen, B.; Straathof, N. J. W.; Milroy, L. -G.; Brunsveld, L.; Hessel, V.; Noël, T. Metal-Free Photocatalytic Aerobic Oxidation of Thiols to Disulfides in Batch and Continuous-Flow. Advanced Synthesis & Catalysis 2015, 357 (10), 2180-2186 DOI: 10.1002/adsc.201401010.
Vural Gürsel, I.; Aldiansyah, F.; Wang, Q.; Noël, T.; Hessel, V. Continuous metal scavenging and coupling to one-pot copper-catalyzed azide-alkyne cycloaddition click reaction in flow. Chemical Engineering Journal 2015, 270, 468-475 DOI: 10.1016/j.cej.2015.02.035.
Vural Gürsel, I.; Noël, T.; Wang, Q.; Hessel, V. Separation/recycling methods for homogeneous transition metal catalysts in continuous flow. Green Chemistry 2015, 17 (4), 2012-2026 DOI: 10.1039/C4GC02160F.
Su, Y.; Talla, A.; Hessel, V.; Noël, T. Controlled Photocatalytic Aerobic Oxidation of Thiols to Disulfides in an Energy-Efficient Photomicroreactor. Chemical Engineering & Technology 2015, 38 (10), 1733-1742 DOI: 10.1002/ceat.201500376.
Borukhova, S.; Seeger, A. D.; Noël, T.; Wang, Q.; Busch, M.; Hessel, V. Pressure-Accelerated Azide-Alkyne Cycloaddition: Micro Capillary versus Autoclave Reactor Performance. ChemSusChem 2015, 8 (3), 504-512 DOI: 10.1002/cssc.201403034.
Habraken, E.; Haspeslagh, P.; Vliegen, M.; Noël, T. Iridium(I)-Catalyzed Ortho -Directed Hydrogen Isotope Exchange in Continuous-Flow Reactors. Journal of Flow Chemistry 2015, 5 (1), 2-5 DOI: 10.1556/JFC-D-14-00033.
Hessel, V.; Noël, T. Topical : what’s new about flow catalysis – Is such ‘Merger’ better for heterocat, homocat and biocat? Chimica Oggi 2015, 33 (2), 2-3.
Hessel, V.; Noël, T. Heterocat, homocat and biocat: what does better flow? Chimica Oggi 2015, 33 (2), 4-8.
Schröder, F.; Ojeda, M.; Erdmann, N.; Jacobs, J.; Luque, R.; Noël, T.; Van Meervelt, L.; Van der Eycken, J.; Van der Eycken, E. V. Supported gold nanoparticles as efficient and reusable heterogeneous catalyst for cycloisomerization reactions. Green Chemistry 2015, 17 (6), 3314-3318 DOI: 10.1039/C5GC00430F.
Schröder, F.; Erdmann, N.; Noël, T.; Luque, R.; Van der Eycken, E. V. Leaching-Free Supported Gold Nanoparticles Catalyzing Cycloisomerizations under Microflow Conditions. Advanced Synthesis & Catalysis 2015, 357 (14-15), 3141-3147 DOI: 10.1002/adsc.201500628.
Noël, T.; Hessel, V. Cross-Coupling Chemistry in Continuous Flow. In New Trends in Cross-Coupling: Theory and Applications; The Royal Society of Chemistry, 2015; pp 610-644; DOI: 10.1039/9781782620259-00610.
2014
Denčić, I.; Ott, D.; Kralisch, D.; Noël, T.; Meuldijk, J.; de Croon, M.; Hessel, V.; Laribi, Y.; Perrichon, P. Eco-efficiency Analysis for Intensified Production of an Active Pharmaceutical Ingredient: A Case Study. Organic Process Research & Development 2014, 18 (11), 1326-1338 DOI: 10.1021/op5000573.
Stouten, S. C.; Noël, T.; Wang, Q.; Hessel, V. Catalyst retention in continuous flow with supercritical carbon dioxide. Chemical Engineering and Processing: Process Intensification 2014, 83, 26-32 DOI: 10.1016/j.cep.2014.03.017.
Straathof, N. J. W.; Gemoets, H. P. L.; Wang, X.; Schouten, J. C.; Hessel, V.; Noël, T. Rapid Trifluoromethylation and Perfluoroalkylation of Five-Membered Heterocycles by Photoredox Catalysis in Continuous Flow. ChemSusChem 2014, 7 (6), 1612-1617 DOI: 10.1002/cssc.201301282.
Hessel, V.; Tibhe, J.; Noël, T.; Wang, Q. Biotechnical Micro-Flow Processing at the EDGE – Lessons to be learnt for a Young Discipline. Chemical and Biochemical Engineering Quarterly Journal 2014, 28 (2), 167-188 DOI: 10.15255/CABEQ.2014.1939.
Gemoets, H. P. L.; Hessel, V.; Noël, T. Aerobic C–H Olefination of Indoles via a Cross-Dehydrogenative Coupling in Continuous Flow. Organic Letters 2014, 16 (21), 5800-5803 DOI: 10.1021/ol502910e.
Baraldi, P. T.; Noël, T.; Wang, Q.; Hessel, V. The accelerated preparation of 1,4-dihydropyridines using microflow reactors. Tetrahedron Letters 2014, 55 (13), 2090-2092 DOI: 10.1016/j.tetlet.2014.02.041.
Su, Y.; Straathof, N. J. W.; Hessel, V.; Noël, T. Photochemical Transformations Accelerated in Continuous-Flow Reactors: Basic Concepts and Applications. Chemistry – A European Journal 2014, 20 (34), 10562-10589 DOI: 10.1002/chem.201400283.
Straathof, N. J. W.; Tegelbeckers, B. J. P.; Hessel, V.; Wang, X.; Noël, T. A mild and fast photocatalytic trifluoromethylation of thiols in batch and continuous-flow. Chemical Science 2014, 5 (12), 4768-4773 DOI: 10.1039/C4SC01982B.
Gürsel, I. V.; Wang, Q.; Noël, T.; Kolb, G.; Hessel, V.; Van Veen, A. C. Heat-integrated novel process of liquid fuel production from bioresources – process simulation and costing study. Chemical Engineering Transactions 2014, 39 (Special Issue), 931-936 DOI: 10.3303/CET1439156.
Hessel, V.; Shahbazali, E.; Noël, T.; Zelentsov, S. Claisen-Umlagerung im Rühr- und Durchflussbetrieb: Verständnis des Mechanismus und Steuerung der Einflussgrößen. Chemie Ingenieur Technik 2014, 86 (12), 2160-2179 DOI: 10.1002/cite.201400125.
Straathof, N.; Osch, D.; Schouten, A.; Wang, X.; Schouten, J.; Hessel, V.; Noël, T. Visible Light Photocatalytic Metal-Free Perfluoroalkylation of Heteroarenes in Continuous Flow. Journal of Flow Chemistry 2014, 4 (1), 12-17 DOI: 10.1556/JFC-D-13-00032.
Zelentsov, S.; Hessel, V.; Shahbazali, E.; Noël, T. The Claisen Rearrangement – Part 1: Mechanisms and Transition States, Revisited with Quantum Mechanical Calculations and Ultrashort Pulse Spectroscopy. ChemBioEng Reviews 2014, 1 (5), 230-240 DOI: 10.1002/cben.201400021.
Hessel, V.; Shahbazali, E.; Noël, T.; Zelentsov, S. The Claisen Rearrangement – Part 2: Impact Factor Analysis of the Claisen Rearrangement, in Batch and in Flow. ChemBioEng Reviews 2014, 1 (6), 244-261 DOI: 10.1002/cben.201400022.
Noël, T.; Hessel, V. Micro Process Technology, 3. Applications. In Ullmann’s Encyclopedia of Industrial Chemistry; Wiley-VCH Verlag GmbH & Co. KGaA: Weinheim, Germany, 2014; pp 1-42; DOI: 10.1002/14356007.o16_o02.
Noël, T. Micro Flow Chemistry: New Possibilities for Synthetic Chemists. In Discovering the Future of Molecular Sciences; Wiley-VCH Verlag GmbH & Co. KGaA: Weinheim, Germany, 2014; pp 137-164; DOI: 10.1002/9783527673223.ch6.
2013
Hessel, V.; Kralisch, D.; Kockmann, N.; Noël, T.; Wang, Q. Novel Process Windows for Enabling, Accelerating, and Uplifting Flow Chemistry. ChemSusChem 2013, 6 (5), 746-789 DOI: 10.1002/cssc.201200766.
Borukhova, S.; Noël, T.; Metten, B.; de Vos, E.; Hessel, V. Solvent- and Catalyst-Free Huisgen Cycloaddition to Rufinamide in Flow with a Greener, Less Expensive Dipolarophile. ChemSusChem 2013, 6 (12), 2220-2225 DOI: 10.1002/cssc.201300684.
Shang, M.; Noël, T.; Wang, Q.; Hessel, V. Packed-Bed Microreactor for Continuous-Flow Adipic Acid Synthesis from Cyclohexene and Hydrogen Peroxide. Chemical Engineering and Technology, 2013, 36, 1001-1009 DOI: 10.1002/ceat.201200703.
Wang, X.; Cuny, G. D.; Noël, T. A Mild, One-Pot Stadler-Ziegler Synthesis of Arylsulfides Facilitated by Photoredox Catalysis in Batch and Continuous-Flow. Angewandte Chemie International Edition 2013, 52 (30), 7860-7864 DOI: 10.1002/anie.201303483.
Stouten, S. C.; Wang, Q.; Noël, T.; Hessel, V. A supported aqueous phase catalyst coating in micro flow Mizoroki–Heck reaction. Tetrahedron Letters 2013, 54 (17), 2194-2198 DOI: 10.1016/j.tetlet.2013.02.064.
Gürsel, I. V.; Wang, Q.; Noël, T.; Hessel, V. Implementation of heat integration for efficient process design of direct adipic acid synthesis in flow. Chemical Engineering Transactions, 2013, 35, 775-780 DOI: dx.doi.org/10.3303/CET1335129.
Kobayashi, H.; Driessen, B.; van Osch, D. J. G. P.; Talla, A.; Ookawara, S.; Noël, T.; Hessel, V. The impact of Novel Process Windows on the Claisen rearrangement. Tetrahedron 2013, 69 (14), 2885-2890 DOI: 10.1016/j.tet.2013.02.038.
Shahbazali, E.; Hessel, V.; Noël, T.; Wang, Q. Metallic nanoparticles made in flow and their catalytic applications in organic synthesis. Nanotechnology Reviews 2013, 3 (1), 65-86 DOI: 10.1515/ntrev-2013-0017.
Denčić, I.; Noël, T.; Meuldijk, J.; de Croon, M.; Hessel, V. Micro reaction technology for valorization of biomolecules using enzymes and metal catalysts. Engineering in Life Sciences 2013, 13 (4), 326-343 DOI: 10.1002/elsc.201200149.
Denčić, I.; de Vaan, S.; Noël, T.; Meuldijk, J.; de Croon, M.; Hessel, V. Lipase-Based Biocatalytic Flow Process in a Packed-Bed Microreactor. Industrial & Engineering Chemistry Research 2013, 52 (32), 10951-10960 DOI: 10.1021/ie400348f.
Noël, T.; Wang, X.; Hessel, V. Accelerating photoredox catalysis in continuous microflow. Chimica Oggi 2013, 31 (3), 10-14.
Noël, T.; Van der Eycken, J. Ferrocene-derived P,N ligands: synthesis and application in enantioselective catalysis. Green Processing and Synthesis 2013, 2 (4), 297-309 DOI: 10.1515/gps-2013-0036.
Vural-Gürsel, I.; Wang, Q.; Noël, T.; Hessel, V.; Tinge, J. T. Improving Energy Efficiency of Process of Direct Adipic Acid Synthesis in Flow Using Pinch Analysis. Industrial & Engineering Chemistry Research 2013, 52 (23), 7827-7835 DOI: 10.1021/ie4002052.
Noël, T.; Hessel, V. Membrane Microreactors: Gas-Liquid Reactions Made Easy. ChemSusChem 2013, 6 (3), 405-407 DOI: 10.1002/cssc.201200913.
Tibhe, J. D.; Fu, H.; Noël, T.; Wang, Q.; Meuldijk, J.; Hessel, V. Flow synthesis of phenylserine using threonine aldolase immobilized on Eupergit support. Beilstein Journal of Organic Chemistry 2013, 9, 2168-2179 DOI: 10.3762/bjoc.9.254.
Stouten, S. C.; Noël, T.; Wang, Q.; Hessel, V. A View Through Novel Process Windows. Australian Journal of Chemistry 2013, 66 (2), 121 DOI: 10.1071/CH12465.
Noël, T.; Hessel, V. Chemical Intensification in Flow Chemistry through Harsh Reaction Conditions and New Reaction Design. In Microreactors in Preparative Chemistry; Wiley-VCH Verlag GmbH & Co. KGaA: Weinheim, Germany, 2013; pp 273-295; DOI: 10.1002/9783527652891.ch11.
2012
Fu, H.; Dencic, I.; Tibhe, J.; Sanchez Pedraza, C. A.; Wang, Q.; Noël, T.; Meuldijk, J.; de Croon, M.; Hessel, V.; Weizenmann, N.; et al. Threonine aldolase immobilization on different supports for engineering of productive, cost-efficient enzymatic microreactors. Chemical Engineering Journal 2012, 207-208, 564-576 DOI: 10.1016/j.cej.2012.07.017.
Cortese, B.; Noël, T.; de Croon, M. H. J. M.; Schulze, S.; Klemm, E.; Hessel, V. Modeling of Anionic Polymerization in Flow With Coupled Variations of Concentration, Viscosity, and Diffusivity. Macromolecular Reaction Engineering 2012, 6 (12), 507-515 DOI: 10.1002/mren.201200027.
Varas, A. C.; Noël, T.; Wang, Q.; Hessel, V. Copper(I)-Catalyzed Azide-Alkyne Cycloadditions in Microflow: Catalyst Activity, High-T Operation, and an Integrated Continuous Copper Scavenging Unit. ChemSusChem 2012, 5 (9), 1703-1707 DOI: 10.1002/cssc.201200323.
Gürsel, I. V.; Hessel, V.; Wang, Q.; Noël, T.; Lang, J. Window of opportunity – potential of increase in profitability using modular compact plants and micro-reactor based flow processing. Green Processing and Synthesis 2012, 1 (4), 315-336 DOI: 10.1515/gps-2012-0046.
Hessel, V.; Noël, T. Micro Process Technology, 2. Processing. In Ullmann’s Encyclopedia of Industrial Chemistry; Wiley-VCH Verlag GmbH & Co. KGaA: Weinheim, Germany, 2012; DOI: 10.1002/14356007.b16_b37.pub2.
Hessel, V.; Noël, T. Micro Process Technology, 1. Introduction. In Ullmann’s Encyclopedia of Industrial Chemistry; Wiley-VCH Verlag GmbH & Co. KGaA: Weinheim, Germany, 2012; DOI: 10.1002/14356007.q16_q01.
Noël, T. Green is the future of chemistry: report of Taminco’s second Green Footsteps Event at the i-SUP 2012. Green Processing and Synthesis 2012, 1 (4), 399-401 DOI: 10.1515/gps-2012-0044.
Bert, K.; Noël, T.; Kimpe, W.; Goeman, J. L.; Van der Eycken, J. Chiral imidate-ferrocenylphosphanes: synthesis and application as P,N-ligands in iridium(I)-catalyzed hydrogenation of unfunctionalized and poorly functionalized olefins. Organic & Biomolecular Chemistry 2012, 10 (42), 8539-8550 DOI: 10.1039/c2ob25871d.
Gürsel, I. V.; Wang, Q.; Noël, T.; Hessel, V. Process-Design Intensification – Direct synthesis of adipic acid in flow. Chemical Engineering Transactions 2012, 29, 565-570 DOI: 10.3303/CET1229095.
Hessel, V.; Vural Gürsel, I.; Wang, Q.; Noël, T.; Lang, J. Potential Analysis of Smart Flow Processing and Micro Process Technology for Fastening Process Development: Use of Chemistry and Process Design as Intensification Fields. Chemical Engineering & Technology 2012, 35 (7), 1184-1204 DOI: 10.1002/ceat.201200038.
Hessel, V.; Gürsel, I. V.; Wang, Q.; Noël, T.; Lang, J. Potenzialanalyse von Milli- und Mikroprozesstechniken für die Verkürzung von Prozessentwicklungszeiten – Chemie und Prozessdesign als Intensivierungsfelder. Chemie Ingenieur Technik 2012, 84 (5), 660-684 DOI: 10.1002/cite.201200007.